I just put at ftp://ftp.red-bean.com/pub/guile/contrib
a port of the Hobbit compiler to Guile. In its current stage, it
should do more good to Guile than harm, and should kill most of the
arguments against Guile's speed.
There is also a non-trivial example provided: compiling boot-9.scm.
It should work out of the box for Linux-Elf and HP-UX.
For other platforms, you must figure out how to
build dynamic libraries. For platforms having only static linking, you
need only add a call to scm_init_* in the
appropriate place in guile.c, and recompile.
Enjoy!
B. Urban